LIGAND.224 family, “PRODRUG COMPOUNDS AND THEIR USES” is pending in US (15/118821), CA, CN, EP, IN, JP with priority to 2/11/2015.

LIGAND.231 family

Pending in CN, EP, HK, JP.

LIGAND.258 family (acetal prodrugs and some platform technology) is pending in the PCT with priority to 1/9/2019.

Erion MD et al. Design, Synthesis, and Characterization of a Series of Cytochrome P450 3A-Activated Prodrugs (HepDirect Prodrugs) 2004 JACS articles

Erion MD et al. Liver-targeted drug delivery using HepDirect prodrugs J Pharmacol Exp Ther 2005; 312:554-560.

Erion MD et al. HepDirect prodrugs for targeting nucleotide-based antiviral durgs to the liver 2006 Investigational Drugs

Carroll et al. Antiviral Efficacy upon Administration of a HepDirect Prodrug August 2011, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Zhi et al. Liver-targeting prodrug (LTP) technology offers new generation nucleotide antiviral agents. EASL ILC Paris, poster-345 (2018)

Zhi et al Liver-targeting prodrug (LTP) technology offers opportunity of new generation lipid lowering agents. NLA Scientific Sessions LV, poster-219 (2018)